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      <image:title>Episode Notes - Hormone Therapy Part 2</image:title>
      <image:caption>Image: from Ray-Coquard et al 2023 Figure 1 Combining endocrine and targeted therapies to overcome resistance. Resistance to endocrine therapies is common in hormone-driven cancers. Current strategies to overcome this resistance are focused on inhibiting upstream signaling pathways and CDK4/6. Approved therapies, and those currently in clinical development (italicized), are depicted with mechanisms of action that include targeting estrogens, estrogen receptor (ER), growth signaling pathways, and CDK4/6.</image:caption>
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      <image:title>Episode Notes - Hormone Therapy Part 1</image:title>
      <image:caption>Image: from Ray-Coquard et al 2023 Figure 1 Combining endocrine and targeted therapies to overcome resistance. Resistance to endocrine therapies is common in hormone-driven cancers. Current strategies to overcome this resistance are focused on inhibiting upstream signaling pathways and CDK4/6. Approved therapies, and those currently in clinical development (italicized), are depicted with mechanisms of action that include targeting estrogens, estrogen receptor (ER), growth signaling pathways, and CDK4/6.</image:caption>
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      <image:title>Episode Notes - Survivorship - From surveillance guidelines paper from SGO. Salani et al. 2017</image:title>
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      <image:title>Episode Notes - Clinical Trial Design - Figure 1.</image:title>
      <image:caption>FACT-G7 (7 questions) over 3 domains - physical, emotional, functional well-being; QOL survey</image:caption>
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      <image:title>Episode Notes - Palliative Care: End of Life - Appendix A</image:title>
      <image:caption>Palliative Performance Scale (PPS) Example</image:caption>
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      <image:title>Episode Notes - Palliative Care: End of Life - Appendix B</image:title>
      <image:caption>Palliative Prognostic Scale (PPI) example</image:caption>
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    <lastmod>2025-04-15</lastmod>
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      <image:title>Episode Notes - Gestational Trophoblastic Neoplasia and GTN Chemotherapy</image:title>
      <image:caption>Image source: https://www.obgproject.com/2018/06/07/gestational-trophoblast-disease-classification-staging/</image:caption>
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      <image:title>Episode Notes - Chemotherapy: Biologics - Figure 1: Receptor Tyrosine Kinases: tyrosine kinases are part of cell surface receptors that bind to growth factors.  When growth factor binding is facilitated, this allows for over expression of cells/proliferation. Tyrosine kinases are appealing therapeutic targets as they are located on the cell surface. Non-receptor kinases are enzymes that phosphorylate proteins in the inner cell membrane and cytoplasm (non cell surface receptor). Include kinases that phosphorylate tyrosine residues of target proteins (SRC family) and specific kinases for serine/threonine residues (AKT family). Phosphatases (like PTEN) oppose activity of kinases), PTEN is a tumor suppressor which negatively regulates the PI3K signaling pathway.</image:title>
      <image:caption>Image from: https://www.nature.com/articles/s41392-022-01168-8</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/65dc8f5a9c52b824432cf105/5e97ce0d-af70-4cd5-b8b1-9ad2cdc4809f/signalling+pathways</image:loc>
      <image:title>Episode Notes - Chemotherapy: Biologics - Figure 2: Pathways and Target Agents: Combining endocrine and targeted therapies to overcome resistance. Resistance to endocrine therapies is common in hormone-driven cancers. Current strategies to overcome this resistance are focused on inhibiting upstream signaling pathways and CDK4/6. Approved therapies, and those currently in clinical development (italicized), are depicted with mechanisms of action that include targeting estrogens, estrogen receptor (ER), growth signaling pathways, and CDK4/6.</image:title>
      <image:caption>Image from: https://www.sciencedirect.com/science/article/pii/S1048891X24014725</image:caption>
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    <lastmod>2025-02-04</lastmod>
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    <lastmod>2024-12-10</lastmod>
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      <image:title>Episode Notes - Radiation: The fundamentals - Figure 1: Point A depiction, brachytherapy dosing</image:title>
      <image:caption>Source: https://www.aboutcancer.com/pointa.jpg</image:caption>
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      <image:title>Episode Notes - Cervix Part 1 - Sedlis’ (Intermediate risk) and Peters’ (High risk) criteria for early stage cervical cancer.</image:title>
      <image:caption>Source: Fleischmann et al. Molecular Markers to Predict Prognosis and Treatment Response in Uterine Cervical Cancer. Cancers. 2021, 13, 5478. https://doi.org/10.3390/cancers13225748</image:caption>
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      <image:title>Episode Notes - Ovary Part 7 - Make it stand out</image:title>
      <image:caption>Figure 1. Narasimhulu 2019, 2023 (8)</image:caption>
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      <image:title>Episode Notes - Chemotherapy principles - Figure 1.</image:title>
      <image:caption>Chemotherapy distribution compartment model, from the SGO ConnectED fellows bootcamp lecture (reference 9 on main references page)</image:caption>
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      <image:title>Episode Notes - Chemotherapy principles - Figure 2.</image:title>
      <image:caption>Tumor growth kinetics (From Antineoplastic Therapies for Gyn Malignancies, reference 5 on main reference page)</image:caption>
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