https://www.readysetgyo.com/episode-notes daily 0.75 2026-03-10 https://www.readysetgyo.com/episode-notes/survivorship monthly 0.5 2025-10-21 https://images.squarespace-cdn.com/content/v1/65dc8f5a9c52b824432cf105/451682a6-e296-4689-8790-3dfff83b4351/Screenshot+2025-10-20+193516.png Episode Notes - Survivorship - From surveillance guidelines paper from SGO. Salani et al. 2017 https://www.readysetgyo.com/episode-notes/clinicaltrialdesign monthly 0.5 2025-10-07 https://images.squarespace-cdn.com/content/v1/65dc8f5a9c52b824432cf105/55111984-496c-4a40-9752-08b934d9076a/FACT-G7 Episode Notes - Clinical Trial Design - Figure 1. 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When growth factor binding is facilitated, this allows for over expression of cells/proliferation. Tyrosine kinases are appealing therapeutic targets as they are located on the cell surface. Non-receptor kinases are enzymes that phosphorylate proteins in the inner cell membrane and cytoplasm (non cell surface receptor). Include kinases that phosphorylate tyrosine residues of target proteins (SRC family) and specific kinases for serine/threonine residues (AKT family). Phosphatases (like PTEN) oppose activity of kinases), PTEN is a tumor suppressor which negatively regulates the PI3K signaling pathway. Image from: https://www.nature.com/articles/s41392-022-01168-8 https://images.squarespace-cdn.com/content/v1/65dc8f5a9c52b824432cf105/5e97ce0d-af70-4cd5-b8b1-9ad2cdc4809f/signalling+pathways Episode Notes - Chemotherapy: Biologics - Figure 2: Pathways and Target Agents: Combining endocrine and targeted therapies to overcome resistance. Resistance to endocrine therapies is common in hormone-driven cancers. Current strategies to overcome this resistance are focused on inhibiting upstream signaling pathways and CDK4/6. Approved therapies, and those currently in clinical development (italicized), are depicted with mechanisms of action that include targeting estrogens, estrogen receptor (ER), growth signaling pathways, and CDK4/6. 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